MEXICO CITY (AP) — Jimmy Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the San Francisco 49ers won their third straight game by beating the Arizona Cardinals 38-10 in Mexico City. It was the fifth regular-season NFL game played in Mexico City and first since 2019. Technically a Cardinals home game, the festive, raucous announced crowd of 78,427 fans heavily favored the 49ers, roaring particularly loud when Kittle and Deebo Samuel scored on 39-yard touchdowns. San Francisco struggled early in the season but has won five of its last seven. The 49ers improved their record to 6-4, while the Cardinals fell to 4-7.
As the final minute ticked off the clock, San Francisco quarterback Jimmy Garoppolo turned toward the crowd at Estadio Azteca, lifted his hands over his head and started clapping.
It was clear that the Mexico City crowd loved the 49ers.
Jimmy G and the 49ers gave that love — and some really good football — right back.
Garoppolo threw four touchdown passes, including two each to Brandon Aiyuk and George Kittle, and the 49ers won their third straight game by blowing past the Arizona Cardinals 38-10 on Monday night in Mexico City.
“The whole atmosphere tonight, I haven’t played in anything like it,” Garoppolo said. “It was electric, the fans were nuts, they were cheering throughout the whole game. It seemed like a soccer game at some points, just the passion they brought. It was really cool. I’d love to do it again.”
It was the fifth regular-season NFL game played in Mexico City and first since 2019. Technically a Cardinals home game, the festive, raucous announced crowd of 78,427 fans heavily favored the 49ers, roaring particularly loud when Kittle and Deebo Samuel each scored on 39-yard touchdowns.
“Man, I love San Francisco, but if we can’t be there, I love to be here,” 49ers coach Kyle Shanahan said. “This place is awesome. That was one of the coolest experiences I’ve been a part of.”
San Francisco (6-4) has won five of its last seven and is tied with the Seahawks at the top of the NFC West. Garoppolo had another efficient performance, completing 20 of 29 passes for 228 yards.
It was a tight game through much of the first half, but the 49ers pulled away in the second half, jumping ahead 24-10 early in the third quarter on a nifty end-around play. Samuel took the pitch and sprinted 39 yards, weaving through the Cardinals defense on his way to the end zone.
“It was really one of those pick your poison type of nights,” Garoppolo said. “They tried to take away the run, so we passed it, and then vice versa. It was a good night.”
It capped a powerful eight-play San Francisco drive that included seven run plays. Aiyuk’s second touchdown catch of the night — this one from 14 yards out — put the 49ers up 31-10 later in the third.
“I hope we made a good impression,” 49ers defensive end Joey Bosa said.
The Cardinals (4-7) played their second straight game without Pro Bowl quarterback Kyler Murray, who has been battling a sore hamstring. Backup Colt McCoy had a 3-1 record in spot starts over the past two seasons — including a win over the Rams last week — but couldn’t recreate the same magic in Mexico.
McCoy finished 24 of 34 passing for 218 yards and an interception. The 49ers hit him hard multiple times, connecting for three sacks.
“It’s just a bummer we didn’t find a way to win that game,” McCoy said. “But San Francisco played hard. They’re a good football team, and we just didn’t make enough plays. But for the crowd, for the atmosphere, being able to play internationally in Mexico City, I thought it was fantastic.”
